TUMORS OF THE MEDIASTINUM

by

YUKIO SHIMOSATO, M.D.
Department of Pathology
Keio University School of Medicine
Shinjuku-Ku
Tokyo 160, Japan
and
National Cancer Center Hospital
Tokyo 104, Japan

KIYOSHI MUKAI, M.D.
Pathology Division
National Cancer Center
Research Institute, East
Kashiwa-Shi, Chiba 277, Japan


Table of Contents

1 Anatomy and Anatomic Compartments of the Mediastinum
  1.1 Normal Thymus Gland
2 Non-Neoplastic Conditions of the Thymus
  2.1 Thymus in Immunodeficiency
    2.1.1 Thymus in Primary Immunodeficiencies
    2.1.2 Thymus in Secondary Immunodeficiencies
  2.2 Thymic Hyperplasia
    2.2.1 True Thymic Hyperplasia
    2.2.2 Lymphoid Hyperplasia
3 Tumors of the Thymus and Related Lesions
  3.1 Classification
  3.2 Thymolipoma and Hamartomatous Lesions
    3.2.1 Thymolipoma
    3.2.2 Ectopic Hamartomatous Thymoma
  3.3 Epithelial Tumors
    3.3.1 Thymoma
    3.3.2 Thymic Carcinoma
  3.4 Carcinoid and Related Tumors
  3.5 Germ Cell Tumors
  3.6 Malignant Lymphoma
    3.6.1 Hodgkin's Disease
    3.6.2 Lymphoblastic Lymphoma
    3.6.3 Large Cell Lymphoma
    3.6.4 Atypical Hyperplastic Lymphoepithelial Lesion and Mucosa-
          Associated Lymphoid Tissue (MALT) Lymphoma
  3.7 Secondary Involvement of the Thymus by Carcinoma and Mesothelioma
      (Including Solitary Fibrous Tumor)
    3.7.1 Secondary Carcinoma Involving the Thymus
    3.7.2 Distinction Between Thymic and Pulmonary Carcinomas
    3.7.3 Mesothelioma Involving the Thymus and Solitary Fibrous Tumor
  3.8 Tumor-Like Lesions of the Thymus
    3.8.1 Thymic Cyst
    3.8.2 Other Tumor-Like Lesions
  3.9 Ectopic Tissues and Tumors in the Anterosuperior Mediastinum
    3.9.1 Thyroid Lesions
    3.9.2 Parathyroid Lesions
4 Tumors of the Mediastinum Excluding the Thymus, Heart, and Great
  Vessels
  4.1 Mesenchymal Tumors
    4.1.1 Benign Mesenchymal Tumors and Tumor-Like Lesions
    4.1.2 Malignant Mesenchymal Tumors
  4.2 Neurogenic Tumors and Tumors of Paraganglia
    4.2.1 Immunohistochemistry of Neurogenic Tumors and Paragangliomas
  4.3 Mediastinal Cysts (Other than Thymic Cyst)
    4.3.1 Bronchogenic Cyst
    4.3.2 Esophageal Cyst
    4.3.3 Gastroenteric Cyst
    4.3.4 Celomic Cyst (Pericardial Cyst and Mesothelial Cyst)
    4.3.5 Thoracic Duct Cyst
    4.3.6 Cyst-Like Lesions Other Than True Cysts
  4.4 Other Mediastinal Tumor-Like Conditions
    4.4.1 Castleman's Disease
5 Index

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