TUMORS OF THE UTERINE CORPUS AND
GESTATIONAL TROPHOBLASTIC DISEASE

by

STEVEN G. SILVERBERG, M.D.
Department of Pathology
George Washington University School of Medicine
Washington D.C. 20037

and

ROBERT J. KURMAN, M.D.
Department of Pathology
Johns Hopkins Hospital
Baltimore, Maryland 21205


Table of Contents

1 Embryology, Gross Anatomy, and Histology
   1.1 Embryology
   1.2 Gross Anatomy
   1.3 Histology
2 Tumor Classification
3 Endometrial Polyps and Hyperplasias
   3.1 Endometrial Polyp
   3.2 Endometrial Hyperplasia
       3.2.1 Other Benign Lesions
       3.2.2 Adenocarcinoma
4 Endometrial Carcinoma
5 Endometrial Stromal Tumors
6 Smooth Muscle and Other Mesenchymal Tumors
   6.1 Leiomyoma
   6.2 Leiomyosarcoma
   6.3 Smooth Muscle Tumor of Uncertain Malignant Potential
   6.4 Other Smooth Muscle Tumors
       6.4.1 Metastasizing Leiomyoma
       6.4.2 Intravenous Leiomyomatosis
       6.4.3 Diffuse Leiomyomatosis
   6.5 Mixed Endometrial Stromal and Smooth Muscle Tumors
   6.6 Adenomatoid Tumor
   6.7 Other Soft Tissue Tumors (Benign and Malignant)
7 Mixed Epithelial-Nonepithelial Tumors
   7.1 Adenofibroma
   7.2 Adenomyoma
   7.3 Adenosarcoma
   7.4 Carcinosarcoma
   7.5 Carcinofibroma
8 Miscellaneous and Secondary Tumors
   8.1 Miscellaneous Tumors
       8.1.1 Sex Cord-Like Tumors
       8.1.2 Tumors of Germ Cell Type
       8.1.3 Neuroectodermal Tumors
       8.1.4 Lymphomas and Leukemias
       8.1.5 Other Miscellaneous Tumors
   8.2 Secondary Tumors
9 Tumor-Like Lesions
   9.1 Epithelial Metaplastic and Related Changes
       9.1.1 Squamous Metaplasia and Morules
       9.1.2 Mucinous Metaplasia
       9.1.3 Ciliary Change
       9.1.4 Hobnail Change
       9.1.5 Clear Cell Change
       9.1.6 Eosinophilic Cell Change
       9.1.7 Surface Syncytial Change
       9.1.8 Papillary Proliferation
       9.1.9 Arias-Stella Change
   9.2 Nonepithelial Metaplastic and Related Changes
       9.2.1 Smooth Muscle Metaplasia
       9.2.2 Osseous and Cartilagenous Metaplasias
       9.2.3 Fatty Change
       9.2.4 Glial Tissue
       9.2.5 Foam Cell Change
   9.3 Adenomyosis
   9.4 Epithelial Cysts of Myometrium
   9.5 Chronic Endometritis
   9.6 Lymphoma-Like Lesions
   9.7 Inflammatory Pseudotumor
   9.8 Other Tumor-Like Lesions
10 Trophoblastic Development
   10.1 Morphologic Aspects of Trophoblastic Development at the
        Implantation Site
   10.2 Functional Aspects of Trophoblastic Differentiation at the
        Implantation Site
11 Classification and Pathology of Gestational Trophoblastic Disease
   11.1 Hydatidiform Mole
   11.2 Complete Hydatidiform Mole (Complete Mole)
   11.3 Partial Hydatidiform Mole (Partial Mole)
   11.4 Invasive Hydatidiform Mole (Invasive Mole)
   11.5 Choriocarcinoma
   11.6 Placental Site Trophoblastic Tumor
   11.7 Exaggerated Placental Site
   11.8 Placental Site Nodule and Plaque
   11.9 Unclassified Trophoblastic Lesions
12 General Aspects of Clinical Management and Staging
13 Index

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