by
RONALD A. DELELLIS, M.D.
Professor, Tufts University School of Medicine
and
Senior Pathologist, New England Medical Center
Boston, Massachusetts 02111
1 Introduction
2 The Normal Parathyroid Gland
2.1 Embryology
2.2 Anatomy
2.2.1 Gross Anatomy
2.2.2 Microscopic Anatomy
2.3 Histochemistry and Immunohistochemistry
2.4 Ultrastructure
3 Physiology
3.1 Normal Physiology
3.1.1 Parathyroid Hormone Biosynthesis
3.1.2 Calcium Homeostasis
3.2 Abnormal Physiology
3.2.1 Hypercalcemia
3.2.2 Hyperparathyroidism
3.2.2.1 Primary Hyperparathyroidism
3.2.2.2 Secondary and Tertiary Hyperparathyroidism
3.2.2.3 Familial Hyperparathyroidism
3.2.2.4 Neonatal Hyperparathyroidism
3.2.3 Other Causes of Hypercalcemia
3.2.3.1 Malignancy-Associated Hypercalcemia
3.2.3.2 Familial Benign (Hypocalciuric) Hypercalcemia
3.2.3.3 Lithium-Associated Hypercalcemia
3.2.3.4 Other Hypercalcemic Syndromes
3.2.4 Parathyroid Glands in Nonparathyroid Hormone-Mediated
Hypercalcemia
4 Parathyroid Adenoma
5 Parathyroid Carcinoma
6 Primary Chief Cell Hyperplasia
7 Clear Cell Hyperplasia
8 Secondary and Tertiary Hyperparathyroidism
8.1 Secondary Hyperparathyroidism
8.1.1 Parathyroid Grafts in Patients with Secondary
Hyperparathyroidism
8.2 Tertiary Hyperparathyroidism
9 Miscellaneous Lesions
9.1 Parathyroid Cyst
9.2 Secondary Tumors
10 Procedures for Pathologic Examination
10.1 Intraoperative and Frozen Section Examination
10.2 Preparation of Tissues for Permanent Sections
10.3 Fat Stains
10.4 Density Gradients
10.5 DNA Cytometry
10.6 Fine-Needle Aspiration Biopsy
11 Index