TUMORS OF THE PARATHYROID GLAND

by

RONALD A. DELELLIS, M.D.
Professor, Tufts University School of Medicine
and
Senior Pathologist, New England Medical Center
Boston, Massachusetts 02111


Table of Contents

1 Introduction
2 The Normal Parathyroid Gland
  2.1 Embryology
  2.2 Anatomy
    2.2.1 Gross Anatomy
    2.2.2 Microscopic Anatomy
  2.3 Histochemistry and Immunohistochemistry
  2.4 Ultrastructure
3 Physiology
  3.1 Normal Physiology
    3.1.1 Parathyroid Hormone Biosynthesis
    3.1.2 Calcium Homeostasis
  3.2 Abnormal Physiology
    3.2.1 Hypercalcemia
    3.2.2 Hyperparathyroidism
      3.2.2.1 Primary Hyperparathyroidism
      3.2.2.2 Secondary and Tertiary Hyperparathyroidism
      3.2.2.3 Familial Hyperparathyroidism
      3.2.2.4 Neonatal Hyperparathyroidism
    3.2.3 Other Causes of Hypercalcemia
      3.2.3.1 Malignancy-Associated Hypercalcemia
      3.2.3.2 Familial Benign (Hypocalciuric) Hypercalcemia
      3.2.3.3 Lithium-Associated Hypercalcemia
      3.2.3.4 Other Hypercalcemic Syndromes
    3.2.4 Parathyroid Glands in Nonparathyroid Hormone-Mediated
          Hypercalcemia
4 Parathyroid Adenoma
5 Parathyroid Carcinoma
6 Primary Chief Cell Hyperplasia
7 Clear Cell Hyperplasia
8 Secondary and Tertiary Hyperparathyroidism
  8.1 Secondary Hyperparathyroidism
    8.1.1 Parathyroid Grafts in Patients with Secondary
          Hyperparathyroidism
  8.2 Tertiary Hyperparathyroidism
9 Miscellaneous Lesions
  9.1 Parathyroid Cyst
  9.2 Secondary Tumors
10 Procedures for Pathologic Examination
  10.1 Intraoperative and Frozen Section Examination
  10.2 Preparation of Tissues for Permanent Sections
  10.3 Fat Stains
  10.4 Density Gradients
  10.5 DNA Cytometry
  10.6 Fine-Needle Aspiration Biopsy
11 Index

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