by
JUAN ROSAI, M.D.
Department of Pathology
Memorial Sloan-Kettering Cancer Center
New York, New York 10021
MARIA LUISA CARCANGIU, M.D.
Department of Pathology
Yale University School of Medicine
New Haven, Connecticut 06510
and
RONALD A. DELELLIS, M.D.
Department of Pathology
Tufts University School of Medicine
and the New England Medical Center
Boston, Massachusetts 02111
1. Introduction
2. The Normal Thyroid Gland
2.1 Embryology
2.2 Anatomy
2.3 Histology
2.3.1 Architectural Features
2.3.2 The Follicular Cell
2.3.3 The C Cell
2.3.4 Solid Cell Nests
2.4 Physiology
2.4.1 Thyroid Hormones
2.4.2 Calcitonin and the Calcitonin Gene-Related Peptide
3. Classification of Thyroid Tumors
4. Follicular Adenoma
4.1 Adenoma Variants
4.1.1 Adenoma with Bizarre Nuclei
4.1.2 Hyalinizing Trabecular Adenoma
4.1.3 Adenolipoma and Adenochondroma
4.1.4 Atypical Adenoma
4.1.5 Adenoma with Papillary Hyperplasia
4.1.6 "Toxic" Adenoma
5. Follicular Carcinoma
5.1 Minimally Invasive (Encapsulated) Type
5.2 Widely Invasive Type
6. Papillary Carcinoma
6.1 Papillary Carcinoma Variants
6.1.1 Papillary Microcarcinoma
6.1.2 Encapsulated Variant
6.1.3 Follicular Variant
6.1.4 Encapsulated Follicular Variant and Related Lesions
6.1.5 Solid/Trabecular Variant
6.1.6 Diffuse Sclerosing Variant
6.1.7 Tall and Columnar Cell Variants
7. Poorly Differentiated Carcinoma
7.1 Insular Carcinoma
7.2 Other Poorly Differentiated Carcinomas
8. Undifferentiated (Anaplastic) Carcinoma
9. Tumors with Oncocytic Features (Hürthle Cell Tumors)
9.1 Oncocytic Adenoma (Hürthle Cell Adenoma)
9.2 Oncocytic Carcinoma (Hürthle Cell Carcinoma)
9.3 Papillary Oncocytic Neoplasms
10. Tumors with Clear Cell Features
11. Tumors with Squamous Features
12. Tumors with Mucinous Features
13. Medullary Carcinoma
13.1 Medullary Carcinoma Variants
13.1.1 Tubular (Follicular) Variant
13.1.2 Papillary Variant
13.1.3 Small Cell Variant
13.1.4 Giant Cell Variant
13.1.5 Clear Cell Variant
13.1.6 Melanotic (Pigmented) Variant
13.1.7 Oncocytic (Oxyphilic) Variant
13.1.8 Squamous Variant
13.1.9 Amphicrine (Composite Calcitonin and Mucin-Producing)
Variant
13.1.10 Paraganglioma-Like Variant
13.1.11 Encapsulated Medullary Carcinoma
13.2 Mixed Medullary-Follicular Carcinoma
13.3 Mixed Medullary-Papillary Carcinoma
14. C Cell Hyperplasia
15. Sarcomas
15.1 Angiosarcoma
16. Malignant Lymphoma
16.1 Other Lymphoid Tumors
16.1.1 Plasmacytoma
16.1.2 Hodgkin Disease
17. Miscellaneous Tumors
17.1 Parathyroid Tumors
17.2 Paraganglioma
17.3 Teratoma
17.4 Benign Soft Tissue-Type Tumors
17.5 Tumors with Thymic or Related Branchial Pouch Differentiation
17.5.1 Ectopic Cervical Thymoma
17.5.2 Ectopic Hamartomatous Thymoma
17.5.3 Spindle Epithelial Tumor with Thymus-Like Differentiation
(SETTLE)
17.5.4 Carcinoma Showing Thymus-Like Differentiation (CASTLE)
17.6 Salivary Gland-Type Tumors
18. Secondary Tumors
19. Tumor-Like Conditions
19.1 Nodular Hyperplasia
19.2 Diffuse Hyperplasia
19.3 Dyshormonogenetic Goiter
19.4 Hashimoto Thyroiditis
19.5 Other Forms of Thyroiditis
19.6 Malakoplakia
19.7 Radiation Changes
19.8 Amyloid Goiter
19.9 Histiocytosis X
19.10 Sinus Histiocytosis with Massive Lymphadenopathy
19.11 Plasma Cell Granuloma
20. Thyroid Tissue in Abnormal Locations
20.1 Ectopia
20.2 Mechanical Implantation
20.3 Parasitic Nodule
20.4 Thyroid Inclusions in Lymph Nodes
20.5 Thyroid as a Component of Teratoma
21. Thyroid Tumors-General Considerations
21.1 Incidence of Thyroid Carcinoma
21.2 Clinical and Laboratory Evaluation of Thyroid Tumors
21.3 Thyroid Tumors in Childhood
21.4 Thyroid Tumors and Radiation Exposure
21.5 Fine-Needle Aspiration Biopsy
21.6 Frozen-Section Examination
21.7 Procedure for Pathologic Examination
21.8 Staging and Grading of Thyroid Carcinoma
21.9 Treatment of Thyroid Tumors
21.10 Prognosis of Thyroid Tumors
21.11 Thyroid Tumors in Animals
22. Index