Item EF310

Tumors of the Heart, Great Vessels, and Serosal Membranes - Fascicles 15 and 16 - 1997 Allen Burke, M.D., Renu Virmani, M.D., Hector Battifora, M.D., and W.T. Elliott McCaughey, M.D.
Tumors of the Heart and Great Vessels The entirely new fascicle on tumors of the cardiovascular system is a comprehensive, 231-page text covering over 50 distinct tumors and tumorlike lesions of the heart and great vessels. Opening the 16-chapter volume are discussions of embryology, overview and incidence of tumors of the heart, and general pathologic and clinical approaches to cardiac tumors. Entities are discussed by putative cell of origin, with emphasis on histogenesis, clinical presentation, radiographic features, gross and microscopic features, and differential diagnosis. Immunohistochemical and ultrastructural findings, where helpful in diagnosis, are discussed and illustrated. A final chapter on metastatic tumors covers the differential diagnosis of metastatic pericardial disease and metastatic tumors to myocardium. There is special emphasis on cardiac myxoma and cardiac sarcomas, which represent the most common primary tumors of the heart, as well as an extensive chapter on mesotheliomas of the pericardium. Newly described lesions, such as cardiac MICE and post-transplant lymphoproliferative diseases, are discussed and illustrated. The text is lavishly illustrated, with over 270 illustrations of gross and microscopic images. The text relies on the vast repository of cardiac tumors at the AFIP as well as on extensive literature citations, emphasizing the most recent references in the 1990's through 1995. There are 18 tables emphasizing incidence, classification, clinical findings, syndromes associated with cardiac tumors, and prognostic data of cardiac sarcomas. Tumors of the Serosal Membranes Since the appearance of the second series fascicle on this topic, there has been considerable growth in our knowledge of these neoplasms, including wider recognition of types of mesothelioma with unusual microscopic features or behavioral patterns. Recent progress in the application of immunohistochemistry has led to more accurate histological diagnosis of mesothelioma and has made it easier to recognize those nonmesothelial tumors mimicking mesothelioma. Nonetheless, hematoxylin and eosin-stained preparations remain the mainstay of diagnosis of serous membrane tumors. Thus, due emphasis is placed on conventional histological findings in this new fascicle, while at the same time expanding the coverage of important diagnostic tests such as immunohistochemistry. In addition to the malignant mesotheliomas, attention is given to other mesothelial-related tumors such as primary serous papillary carcinoma of the peritoneum, multicystic mesothelioma, intra-abdominal desmoplastic round cell tumor, adenomatoid tumor, localized fibrous tumor, and the so-called mesothelioma of the atrioventricular node. Concise tables depict such features as: the differential diagnosis of diffuse malignant mesothelioma; the comparison of histologic features of mesothelial hyperplasia, mesothelioma, and carcinoma; and the immunohistochemistry of peritoneal mesothelioma and serous carcinoma. The fascicle is 128 pages long and includes over 150 illustrations, 104 of which are in color. It should be an essential reference for pathologists in practice and in training.

Tumors of the Heart, Great Vessels, and Serosal Membranes - Fascicles 15 and 16 - 1997
Allen Burke, M.D., Renu Virmani, M.D., Hector Battifora, M.D., and W.T. Elliott McCaughey, M.D.

Tumors of the Heart and Great Vessels The entirely new fascicle on tumors of the cardiovascular system is a comprehensive, 231-page text covering over 50 distinct tumors and tumorlike lesions of the heart and great vessels. Opening the 16-chapter volume are discussions of embryology, overview and incidence of tumors of the heart, and general pathologic and clinical approaches to cardiac tumors. Entities are discussed by putative cell of origin, with emphasis on histogenesis, clinical presentation, radiographic features, gross and microscopic features, and differential diagnosis. Immunohistochemical and ultrastructural findings, where helpful in diagnosis, are discussed and illustrated. A final chapter on metastatic tumors covers the differential diagnosis of metastatic pericardial disease and metastatic tumors to myocardium. There is special emphasis on cardiac myxoma and cardiac sarcomas, which represent the most common primary tumors of the heart, as well as an extensive chapter on mesotheliomas of the pericardium. Newly described lesions, such as cardiac MICE and post-transplant lymphoproliferative diseases, are discussed and illustrated. The text is lavishly illustrated, with over 270 illustrations of gross and microscopic images. The text relies on the vast repository of cardiac tumors at the AFIP as well as on extensive literature citations, emphasizing the most recent references in the 1990's through 1995. There are 18 tables emphasizing incidence, classification, clinical findings, syndromes associated with cardiac tumors, and prognostic data of cardiac sarcomas. Tumors of the Serosal Membranes Since the appearance of the second series fascicle on this topic, there has been considerable growth in our knowledge of these neoplasms, including wider recognition of types of mesothelioma with unusual microscopic features or behavioral patterns. Recent progress in the application of immunohistochemistry has led to more accurate histological diagnosis of mesothelioma and has made it easier to recognize those nonmesothelial tumors mimicking mesothelioma. Nonetheless, hematoxylin and eosin-stained preparations remain the mainstay of diagnosis of serous membrane tumors. Thus, due emphasis is placed on conventional histological findings in this new fascicle, while at the same time expanding the coverage of important diagnostic tests such as immunohistochemistry. In addition to the malignant mesotheliomas, attention is given to other mesothelial-related tumors such as primary serous papillary carcinoma of the peritoneum, multicystic mesothelioma, intra-abdominal desmoplastic round cell tumor, adenomatoid tumor, localized fibrous tumor, and the so-called mesothelioma of the atrioventricular node. Concise tables depict such features as: the differential diagnosis of diffuse malignant mesothelioma; the comparison of histologic features of mesothelial hyperplasia, mesothelioma, and carcinoma; and the immunohistochemistry of peritoneal mesothelioma and serous carcinoma. The fascicle is 128 pages long and includes over 150 illustrations, 104 of which are in color. It should be an essential reference for pathologists in practice and in training.