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SARS Case 1
Autopsy, Singapore


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Radiograph from day 9 reveals patchy areas of consolidation primarily in the mid and lower lung zones bilaterally. (copyright 2003, contributed by Tan Tock Seng Hospital, Singapore, all rights reserved.) Radiograph from day 11 demonstrates diffuse, symmetric involvement of both lungs. (copyright 2003, contributed by Tan Tock Seng Hospital, Singapore, all rights reserved.)

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Radiograph from day 13 reveals worsening. The patient is now intubated. (copyright 2003, contributed by Tan Tock Seng Hospital, Singapore, all rights reserved.)

 


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Figure 1. Homogeneous appearing hyaline membranes (arrow) line edematous alveolar walls (H&E stain, 200x).

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Figure 2. Organizing DAD is characterized by loose fibroblastic proliferation in alveolar spaces (arrow) and within the interstitium (arrowhead) and type II pneumocyte hyperplasia (H&E stain, 100x).

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Figure 3. Acute bronchopneumonia is characterized by polymorphonuclear leukocytes filling alveolar spaces, and in this case is associated with alveolar hemorrhage (H&E stain, 200x).

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Figure 4. Cytologically atypical epithelial cells are present within alveolar spaces (H&E, 400x).

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Figure 5. Digital slide of diffuse alveolar damage (H&E).
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Website created: May 1, 2003. Last updated: February 18, 2004